"Thoughts and prayers of the university are with Mike and (wife) Sharon and their family," the school said in a statement.
Mississippi State coach Mike Leach was hospitalized Sunday after what the university called "a personal health issue" that happened at his home in Starkville.
The 61-year-old Leach was initially treated at a local hospital before being airlifted to the University of Mississippi Medical Center in Jackson.
UMMC spokesman Marc Rolph said Leach was listed as a patient at the hospital, but had no information regarding the coach's condition.
"Prayers for Coach Leach and family. We're all on the same team tonight," Mississippi athletic director Keith Carter posted on Twitter.
Defensive coordinator Zach Arnett has been placed in charge of the football team by Mississippi State President Mark Keenum.
Leach is in his third season at Mississippi State, with a 19-17 record. He acknowledged a bout with pneumonia late in the season that was causing a persistent cough.
Leach, known for his prolific Air Raid offenses, is 158-107 in 21 seasons as a head coach at Texas Tech, Washington State and Mississippi State.